Nrf2 activator cancer. Here in this research, we systematically review the function a...

Nrf2 activator cancer. Here in this research, we systematically review the function and role of Nrf2 signaling pathway in several typical malignant tumors, summarize the recent progress of Nrf2 in cancer treatment and elaborate the current status and potential therapeutic targetable role of Nrf2. 1. However, permanent activation of Nrf2 promotes various cancer properties, comprising malignant progression, chemo/radio resistance, and poor patient prognosis. , ABC1, SW900) as well as KEAP1-mutant controls (e. We show that NRF2 activation stimulates cell growth, whereas miR-29b-1-5p overexpression reduces cell proliferation. Mar 1, 2024 · Dysfunction of the NRF2 pathway leads to the activation of cellular defense systems and subsequent target gene upregulation, thereby promoting the survival and proliferation of cancer cells. Aug 15, 2025 · However, aberrant NRF2 activation occurs in cancer due to mutations in the KEAP1/NRF2 pathway, and it contributes to the generation of a tumor microenvironment that favors the proliferation, survival, and chemoresistance of cancer cells. Taken together, our experimental results suggest that low-dose antimony exposure promotes PCa cell proliferation by inhibiting ferroptosis through activation of the Nrf2-SLC7A11-GPX4 pathway. Oct 17, 2025 · Clinical observations have revealed that NRF2 hyperactivation in cancer cells is often associated with immune suppression in the tumor microenvironmen… Nrf2 has been associated with conditions like cancer and neurodegenerative diseases. Apr 10, 2025 · Nrf2 is essential for maintaining skin homeostasis and regulating inflammation. , A549) to demonstrate specificity [4]. ML385 reversed THC's protective effects, confirming the involvement of the Keap1/Nrf2 signaling pathway. Among the different pathways that control NRF2, non-coding RNA transcripts play a significant role, and by altering NRF2 expression, they influence tumor development. This review highlights the multifaceted role of Nrf2 in skin inflammatory diseases like atopic dermatitis and psoriasis Ferroptosis markers, oxidative stress, and iron metabolism were evaluated, alongside Nrf2-GPX4 pathway activation and ferritin (FTH/L) expression. In cancer aberrant Nrf2 activation may lead to enhanced tumor survival by increasing expression of cytoprotective genes which makes cancer cells resistant to chemotherapy. Paradoxically, cancer cells hijack Nrf2 signaling, and Nrf2 activators turn out to accelerate tumor progression and metastasis in mice [11 - 13]. Sep 13, 2025 · Constitutive activation of NRF2 is a common event in cancer and recent advances provide remarkable insights into the role of NRF2 in oncogenesis, immune evasion, and treatment resistance. Sep 13, 2025 · Constitutive activation of NRF2 is a common event in cancer and recent advances provide remarkable insights into the role of NRF2 in oncogenesis, immune evasion, and treatment resistance. In this respect, mounting evidence supports that tumors are addicted to Nrf2 signaling [14, 15] and some Nrf2-dependent signaling pathways are linked to clinical aggressiveness of cancer cells [15 - 18]. CONCLUSION: THC inhibits ferroptosis through the activation of the Keap1/Nrf2 signaling pathway, significantly improving BBB dysfunction and alleviating neurological deficits following cerebral ischemia-reperfusion. Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes. Understanding the regulation of Nrf2 activity and downstream pathways has major implications for human health. Jun 2, 2025 · The elevation of glycolysis, activation of epithelial-mesenchymal transition (EMT), and inhibition of ferroptosis are additional features of NRF2 upregulation in human cancers. Cell Culture and Treatment: Use lung cancer cell lines with a functional KEAP1-NRF2 system (e. Mar 7, 2023 · NRF2 has been studied extensively in KEAP1-mutant cancers; however, the role of this pathway in cancers with wild-type KEAP1 remains poorly understood. Jun 30, 2022 · Transient Nrf2 activation, by its specific activators, has protective roles against carcinogenesis and cancer development. It is therefore controversial whether the activation, or alternatively the inhibition, of NRF2 is a useful strategy for the prevention or treatment of cancer. Mar 4, 2025 · Persistent activation of NRF2 in cancer contributes to cancer progression, metastasis and resistance to chemotherapeutic drugs, radiotherapy and ferroptosis inducers. More recently, genetic analyses of human tumours have indicated that NRF2 may conversely be oncogenic and cause resistance to chemotherapy. Nov 25, 2019 · NRF2 and miR-29b-1-5p are two opposite forces, which could regulate the fate of MDA-MB-231 triple-negative breast cancer (TNBC) cells. . g. This protocol is based on experiments used to demonstrate that the KRASG12C inhibitor Sotorasib also acts as an NRF2 activator [4]. To answer this question, we induced NRF2 via pharmacological inactivation of KEAP1 in a panel of 50+ non-small cell lung cancer cell lines. Results: Iron dysregulation and oxidative stress contributed to DSS-induced colitis by activating ferroptosis in colonic epithelial cells. pkjfvrmly qftp gtisj lvx sle hzugr qyppxxmx pztmw chffp tzdqde